Upcoming Events

  • Nov

    20

    PMI Seminar

    David Sept, PhD

    November 20, 2017 @ 2pm

    CRB Austrian Aud.


  • Nov

    27

    PMI Seminar

    Robin Shaw, MD, PhD

    November 27, 2017 @ 2pm

    CRB Austrian Aud.


  • Nov

    28

    PMI Muscle Club

    Leon Morales

    November 28, 2017 @ 1pm

    702 CRB


  • Nov

    29

    PMI Journal Club

    Practice Talks

    November 29, 2017 @ 12pm

    702 CRB


  • Dec

    07

    Special Seminar

    Carsten Grashoff, PhD

    December 7, 2017 @ 12pm

    CRB Austrian Aud.


  • Dec

    11

    PMI Seminar

    John A. Hammer, PhD

    December 11, 2017 @ 2pm

    CRB Austrian Aud.


  • Dec

    12

    PMI Muscle Club

    Alexandra Stanley

    December 12, 2017 @ 1pm

    702 CRB


  • Jan

    08

    PMI Seminar

    Mattthias Rief, PhD

    January 08, 2018 @ 2pm

    CRB Austrian Aud.


  • Jan

    09

    PMI Muscle Club

    Hansell Stedman

    January 09, 2017 @ 1pm

    702 CRB


  • Jan

    10

    PMI Journal Club

    Julie Heffler

    January 10, 2018 @ 12pm

    702 CRB


  • Jan

    17

    PMI Journal Club

    Ekaterina Grishchuk

    January 17, 2018 @ 12pm

    702 CRB


  • Jan

    22

    PMI Seminar

    Matthew Welch, PhD

    January 22, 2018 @ 2pm

    CRB Austrian Aud.


  • Jan

    23

    PMI Muscle Club

    Zoltan Arany

    January 23, 2017 @ 1pm

    702 CRB


  • Jan

    29

    PMI Seminar

    Boris Hinz, PhD

    January 29, 2018 @ 2pm

    CRB Austrian Aud.


  • Feb

    12

    PMI Seminar

    Taekjip Ha, PhD

    February 12, 2018 @ 2pm

    CRB Austrian Aud.


  • Feb

    13

    PMI Muscle Club

    Julie Heffler

    February 13, 2018 @ 1pm

    702 CRB


  • Feb

    27

    PMI Muscle Club

    Julianne Huegel

    February 27, 2018 @ 1pm

    702 CRB


  • Mar

    5

    PMI Seminar

    Jennifer DeLuca, PhD

    March 5, 2018 @ 2pm

    CRB Austrian Aud.


  • Mar

    12

    PMI Seminar

    Christine Beattie, PhD

    March 12, 2018 @ 2pm

    CRB Austrian Aud.


  • Mar

    13

    PMI Muscle Club

    Joseph Baur

    March 13, 2018 @ 1pm

    702 CRB


  • Mar

    26

    PMI Seminar

    Sigmar Stricker, PhD

    March 26, 2018 @ 2pm

    CRB Austrian Aud.


  • Mar

    27

    PMI Muscle Club

    Timothy Luongo

    March 27, 2018 @ 1pm

    702 CRB


  • Mar

    19

    PMI Seminar

    David Drubin, PhD

    March 19, 2018 @ 2pm

    CRB Austrian Aud.


  • Apr

    02

    PMI Seminar

    Matthew C. Good, PhD

    April 2, 2018 @ 2pm

    CRB Austrian Aud.


  • Apr

    09

    PMI Seminar

    P. Todd Stukenberg, PhD

    April 9, 2018 @ 2pm

    CRB Austrian Aud.


  • Apr

    10

    PMI Muscle Club

    Alexandra Stanley

    April 10, 2018 @ 1pm

    702 CRB


  • Apr

    23

    PMI Seminar

    Xavier Trepat, PhD

    April 23, 2018 @ 2pm

    CRB Austrian Aud.


  • Apr

    24

    PMI Muscle Club

    Eddie Bonnevie

    April 24, 2018 @ 1pm

    702 CRB


  • Apr

    30

    PMI Seminar

    Jennifer Curtis, PhD

    April 30, 2018 @ 2pm

    CRB Austrian Aud.


  • May

    08

    PMI Muscle Club

    Leon Morales

    May 8, 2018 @ 1pm

    702 CRB


  • May

    22

    PMI Muscle Club

    Quentin McAffee

    May 22, 2018 @ 1pm

    702 CRB

Recent News

  • Thanks to all who participated in the 2017 PMI Retreat and Symposium. Learn more HERE

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  • The Journal of Cell Science has listed PMI Member Melike Lakadamyali as a Cell Scientist to watch. See the press release HERE

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  • Congratulations to Yale E. Goldman, MD, PhD on being elected to National Academy of Science. See details HERE

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  • Congratulations to Prof. Clara Franzini-Armstrong for being named a 2017 Honorary Degree Recipient! This is one of the University of Pennsylvania’s highest honors. See details HERE

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  • Congratulations to Ben Prosser for receiving the 2017 Linda Pechenik Montague Investigator Award!DETAILS HERE>

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  • Congratulations to Betsy McIntosh (Ostap/Holzbaur Labs) for receiving her PhD after successfully defending her thesis!

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  • See Press Release about Penn’s newly created Center for Engineering Mechanobiology, headed by Profs. Yale E. Goldman and Vivek Shenoy, HERE

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  • Listen to Dr. Erika Holzbaur interviewed on NPR regarding Nobel Prize awarded to Dr. Yoshinori Ohsumi for autophagy: HERE

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  • Congratulations to Yale Goldman, Vivek Shenoy, Rebecca Wells and colleagues for being awarded NSF funds to launch the STC Center for Engineering MechanoBiology. See NSF press release HERE

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  • Read Press Release about the work from the Khurana and Baur Labs describing the consequences of NAD deficiency on muscle function. HERE

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  • The Goldman Lab finds that a powerstroke within the ribosome is required for translocation in protein synthesis. See PNAS paper here

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  • The Prosser Lab finds a key mechanical role for microtubules in health and disease. See Penn press release and Science article here

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  • Congratulations to Prof. Erika Holzbaur for winning the Jane M. Glick Graduate Student Teaching Award! This award recognizes excellence in teaching and mentorship in Penn’s Biomedical Graduate Studies program.

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  • Thanks to all who participated in the PMI Retreat and Symposium. Learn more

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  • Biophysical Journal Cover highlights work from the Grishchuk Lab. See article HERE and cover image HERE

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  • Dr. David Kast has been chosen to present his research at the “Future of Biophysics Symposium” at the 2016 Biophysical Society Meeting in Los Angeles. See details here.

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  • Congratulations to Erika Holzbaur for being awarded the 2015 Stanley N. Cohen Biomedical Research Award from the Perelman School of Medicine! This elite award recognizes research excellence in the basic sciences at Penn.

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  • Congratulations to Drs. Prosser, Discher, and Liu for receiving the 2015 Kaufman Foundation Initiative Award. See details here.

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  • Congratulations to Dr. Yale E. Goldman for winning the Biophysical Society’s Distinguished Service Award. Details here.

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  • Our sincere thanks to Drs. Ekaterina Grishchuk and Ben Prosser for organizing an outstanding 2014/15 PMI seminar series HERE. Stay tuned for the 2015/16 schedule being organized by Drs. Anna Kashina and Mike Ostap.

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  • The Kashina Lab discovers a novel protein modification that regulates purine nucleotide biosynthesis. See paper HERE and Penn press release HERE

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  • Please see the tribute to the incredible career of our PMI colleague, Prof. Howard Holtzer written by Drs. Stockdale, Sanger and EmersonHERE

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  • Congratulations to Erika Holzbaur for being selected as the recipient of the American Neurological Association’s 2015 F.E. Bennett Memorial Lectureship Award. This award was established in 1979 by Dr. Abram Elting Bennett in memory of his son Foster E. Bennett, MD, and is presented annually to an outstanding researcher and educator in neurology

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  • The Dominguez Lab finds protein "Comet Tails” that propel a cell recycling process. See Penn press releaseHERE and
    and the Current Biology paper HERE

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  • The Lampson and Black Labs identify key protein-DNA interactions important for chromosome inheritance. Read the Science paper HERE

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  • The Sweeney Lab characterizes a key step important for force generation in myosins. Read the Developmental Cell paper HERE

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  • The Grishchuk Lab and colleagues discover the “tubulin code” for chromosome movement during mitosis. See details HERE

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  • Congratulations to Meredith Wilson of the Holzbaur Lab who is a CAMB winner of the 2015 Saul Winegrad Award for Outstanding Dissertation!

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  • Congratulations to Janelle Spinazzola (Barton/Sweeney Labs) for receiving her PhD after successfully defending her thesis! Janelle has been a trainee on the PMI T32 Training Grant.

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  • Congratulations to Jeff Nirschl (Holzbaur Lab) for being awarded a prestigious F30 fellowship from NINDS/NIH!

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  • Janelle Spinazzola (PMI T32 trainee) in Elisabeth Barton’s Lab uncovers a key mechanosensing molecule in the dystrophin complex. Details can be found HERE

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  • Students and Post-Docs: Apply for the Annemarie Weber Prize for Research Presentation and Participation. Deadline February 2. HERE

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  • Images from PMI scientists featured at Philadelphia International Airport art exhibit. See details and slide show HERE

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  • The Bi and Svitkina Labs obtain an unparalleled view of septin structures within cells and define septin remodelling dynamics during the cell cycle. DETAILS

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  • The Lindstrom Lab demonstrates efficacy for vaccine for myasthenia gravis. See press release HERE

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  • Dr. Ekaterina Grishchuk is the 2014 recipient of Michael S. Brown New Investigator Research Award. Congratulations Katya!

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  • Please read the Penn Medicine press release regarding the Pennsylvania Muscle Institute's NIH PO1 HERE

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  • Congratulations to the PMI team of Ostap, Dominguez, Goldman, Holzbaur, and Shuman for receiving a renewal of their NIH PO1!

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  • Congratulations to Ryan Jamiolkowski (Goldman Lab) for receiving a Ruth L. Kirschstein Award (F30) from NIH.

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  • The Dominguez Lab determines how actin filaments are capped in muscle fibers. See Article in Science HERE

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  • Sandra Maday in the Holzbaur Lab resolves crucial steps in autophagosome biogenesis. HERE

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  • Congratulations to Michael Greenberg (Ostap Lab) for receiving a prestigious Pathway to Independence Award (K99/R00) award from NIH/NHLBI.

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  • Meredith Wilson (Holzbaur Lab) wins award for best poster by a graduate student at the Gordon Research Conference on Muscle & Molecular Motors. This prestigious award was sponsored by the Lymn Foundation HERE Meredith is a former PMI T32 trainee.

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Recent Publications



Our Facilities

The PMI is prominent in technological and methodological development, especially in advanced light microscopy, structural spectroscopy, force spectroscopy, nanotechnology, and biochemical kinetics. Additionally, the PMI offers unique muscle assessment technologies to our members. To learn more about our facilities and services, please click below.

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