Faculty

Marie A Guerraty, MD, PhD

Assistant Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania

Department: Medicine

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

11-103 Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104

Office: 215-746-1449

Email:
marie.guerraty@pennmedicine.upenn.edu

Education:
BS (Mathematics)
Duke University, Durham, NC, 2003.
PhD (Bioengineering)
University of Pennsylvania School of Engineering and Applied Sciences, 2008.
MD (Medicine)
University of Pennsylvania Perelman School of Medicine, 2010.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

cardiac imaging, cardiac PET, myocardial blood flow, transthoracic echocardiography, ischemic heart disease, coronary artery disease, coronary microvascular disease

Description of Research Expertise

ischemic heart disease, vascular biology, coronary artery disease, vascular biology, coronary microvascular disease, nuclear cardiology, Perfusion PET, small animal cardiac imaging, functional genomics, transcriptional regulation, FOG2, ZFPM2, TWIST1

Selected Publications

Jakob Woerner, Thomas M Westbrook, Jaehyun Joo, Manu Shivakumar, Rasika Venkatesh, Tess Cherlin, Sang-Hyuk Jung, Seokho Jeong, Damian Maseda, Michelle McKeague, Matei Ionita, Joost Wagenaar, Sarah A Abramowitz, Anurag Verma, Bingxin Zhao, Seunggeun Lee, Scott Damrauer, Michael G Levin, Su Chin Heo, Thomas P Cappola, Daniel J Rader, Sharlene Day, Rajat Deo, Joel M Gelfand, Ravi Ramessur, Marie A Guerraty, Shefali Setia-Verma, Bogdan Pasaniuc, Marylyn D Ritchie, Sokratis A Apostolidis, Allison R Greenplate, E John Wherry, Penn Medicine Biobank, Yonghyun Nam, Dokyoon Kim: Large-scale evaluation of proteomic and polygenic risk scores reveals complementary contributions to incident disease prediction. MedRxiv 2025.

Rasika Venkatesh, Tess Cherlin, Nicole Wayne, Rachit Kumar, Lindsay Guare, Venkata P. Singamneni, Brett Irving, Scott Dudek, Regeneron Genetics Center, Penn Medicine Biobank, Michael G. Levin, Shefali Setia-Verma, Marie A. Guerraty3†: Genome-Wide Association Study of Coronary Microvascular Disease assessed by cardiac perfusion Positron Emission Tomography converges on NF-KB pathway MedRxiv 2025.

Rasika Venkatesh, Tess Cherlin, Penn Medicine BioBank, Marylyn D Ritchie, Marie A Guerraty, Shefali S Verma: Integrating Imaging-Derived Clinical Endotypes with Plasma Proteomics and External Polygenic Risk Scores Enhances Coronary Microvascular Disease Risk Prediction. medRxiv 2025.

Nicole Wayne, Venkata S Singamneni, Rasika Venkatesh, Tess Cherlin, Shefali S Verma, Marie A Guerraty: Genetic Insights Into Coronary Microvascular Disease. Microcirculation 2025.

N Wayne, MA Guerraty: Functional genomics identifies a protective role for FDX1 in atherosclerosis. Nature Cardiovascular Research 2025.

DJ Stentz, M Kumar, MA Guerraty, SD Metzler: Constraints on Kinetic-Model Fitting that Yield Unique Solutions for 99mTc-Teboroxime. IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD) 2024.

S Gurunathan, T Sakamoto, D Conlon, D Kelly, M Guerraty: The Transcriptional Regulator FOG2S Represses GATA4-ERRalphaPGC1alpha Complex to Decrease Mitochondrial Metabolism. Circulation Research 135(suppl_1), 2024.

N Wayne, Q Wu, SC Moore, VA Ferrari, SD Metzler, MA Guerraty: Multimodality assessment of the coronary microvasculature with TIMI frame count versus perfusion PET highlights coronary changes characteristic of coronary microvascular disease. Frontiers in Cardiovascular Medicine 2024.

Welch E, Guerraty MA, ..., Ky B, Narayan V.: Coronary Microvascular Dysfunction in Men with Prostate Cancer Receiving Androgen-Deprivation Therapy. Clinical Genitourinary Cancer 2024.

Donna M. Conlon 1,Siri Kanakala 1,Tess Cherlin 2ORCID,Yi-An Ko 3,Cecilia Vitali 1,Sharavana Gurunathan 1ORCID,Rasika Venkatesh 3ORCID,Jakob Woerner 4,Lindsay A. Guare 2ORCID,Penn Medicine Biobank 5,Anurag Verma 1,Shefali S. Verma 2 andMarie A. Guerraty 1,*: Genotype-First Approach Identifies an Association between rs28374544/FOG2S657G and Liver Disease through Alterations in mTORC1 Signaling. Genes 2024.