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Roberto Dominguez, Ph.D.
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William Maul Measey Presidential Professor of Physiology II
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Department: Physiology
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Department of Physiology
23 Perelman School of Medicine
22 University of Pennsylvania
22 728 Clinical Research Bldg
36 415 Curie Blvd
Philadelphia, PA 19104-6085
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23 Perelman School of Medicine
22 University of Pennsylvania
22 728 Clinical Research Bldg
36 415 Curie Blvd
Philadelphia, PA 19104-6085
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Office: 215-573-4559
32 Fax: 215-573-2273
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32 Fax: 215-573-2273
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Education:
21 a M.S. 2e (Theoretical Physics & Mathematics) c
52 Faculty of Physics, Odessa State University (former USSR), 1987.
21 a Ph.D. 35 (Protein Crystallography and Biochemistry) c
52 Pasteur Institute and Paris-Sud University, Paris, France, 1996.
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21 a M.S. 2e (Theoretical Physics & Mathematics) c
52 Faculty of Physics, Odessa State University (former USSR), 1987.
21 a Ph.D. 35 (Protein Crystallography and Biochemistry) c
52 Pasteur Institute and Paris-Sud University, Paris, France, 1996.
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Links
cc Search PubMed for articles
5c Dominguez Lab
79 BMB Graduate Group
77 Physiology Department
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Permanent linkcc Search PubMed for articles
5c Dominguez Lab
79 BMB Graduate Group
77 Physiology Department
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13f Cytoskeletal proteins control a myriad of fundamental cellular activities, including cell locomotion, intracellular transport, endo- and exocytosis. Dysfunction of cytoskeletal components is often associated with devastating diseases, such as cancer and several muscular, immune and neurodegenerative disorders.
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2a5 Cytoskeletal proteins often form large functional assemblies, and additionally associate with cellular membranes. Therefore, our goal is to study their structures and activities within the context of such protein-protein and protein-membrane interaction networks. An important tool in our research is X-ray crystallography. The atomic “snapshots” resulting from crystal structures provide a wealth of knowledge, but lack information about the dynamic aspects of protein function. To obtain this kind of information we use a host of other approaches, including molecular biology, bioinformatics, biophysical methods (ITC, MALS, FRET, TIRF, Cryo-EM), and cell biology.
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Description of Research Expertise
160 My laboratory studies the proteins that control the actin cytoskeleton and cytoskeleton-membrane connections, as well as the signaling cascades that regulate their activities. We use a broad spectrum of experimental approaches, spanning structural biology, biochemistry and cell biology, allowing us to correlate structure to function.8
13f Cytoskeletal proteins control a myriad of fundamental cellular activities, including cell locomotion, intracellular transport, endo- and exocytosis. Dysfunction of cytoskeletal components is often associated with devastating diseases, such as cancer and several muscular, immune and neurodegenerative disorders.
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2a5 Cytoskeletal proteins often form large functional assemblies, and additionally associate with cellular membranes. Therefore, our goal is to study their structures and activities within the context of such protein-protein and protein-membrane interaction networks. An important tool in our research is X-ray crystallography. The atomic “snapshots” resulting from crystal structures provide a wealth of knowledge, but lack information about the dynamic aspects of protein function. To obtain this kind of information we use a host of other approaches, including molecular biology, bioinformatics, biophysical methods (ITC, MALS, FRET, TIRF, Cryo-EM), and cell biology.
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