Faculty

Alexander C Huang, MD

Assistant Professor of Medicine (Hematology-Oncology)

Department: Medicine

Graduate Group Affiliations

Contact information

Room 714, Biomedical Research Building II/III
421 Curie Blvd
Philadelphia, PA 19104

Email:
alexander.huang@pennmedicine.upenn.edu

Education:
BS (Science, Biomedical Engineering )
Johns Hopkins University , 2005.
MD
Mount Sinai School of Medicine , 2010.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Wang H, Liu S, Sinha P, Liu F, Zhang X, Guo Y, Goncalves B, Zheng Q, Mou H, Yang J, Huang L, Miao F, Zeng T, Karakousis G, Huang AC, Mitchell T, Amaravadi R, Schuchter L, Milone M, Guo W, June C, Herlyn M, Fan Y, Xu X: DR5 CAR-T cells target melanoma and suppress MDSCs with minimal toxicity. Molecular Therapy 34(3), March 2026.

Messing I, Linkowski L, Riina MD, Berger M, Baron J, Wang X, Kallan M, Hubbeling HG, Lustig RA, Dorsey JF, Kurtz G, Nagda S, Lukens JN, Flowers A, Lee JYK, Amankulor NM, Jackson C, Mohan S, Amaravadi RK, Schuchter LM, Huang AC, Mitchell TC, Alonso-Basanta M, Lebow ES: Outcomes after SRS and ipilimumab plus nivolumab for melanoma brain metastases following prior immune checkpoint inhibitor or targeted therapy. Oncologist 31(4), March 2026.

Park SL, Painter MM, Manne S, Alcalde V, McLaughlin M, Sullivan MA, Mathew D, Torres L, Huang YJ, Reeg DB, Douek NR, Campos T, Klapholz M, Cardenas MA, Fang V, Ngiow SF, Kc W, Goel RR, Baxter AE, Wu JE, Tan M, Berry CT, Ellebrecht CT, Huang AC, Papazian E, Liu Y, Rajasekaran K, Brody RM, Thaler ER, Basu D, Diab A, Giles JR, Wherry EJ: Tissue-resident exhausted and memory CD8(+) T cells have distinct ontogeny, function and role in disease. Nature Immunology 27(1), January 2026.

Lucas MW, Burton EM, Dimitriadis P, Huang AC, Long GV, Mitchell TC, Amaria RN, Blank CU: Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity. Immunity 59(1), January 2026.

Wang G, Yoon D, Nandi A, Patel K, Azar T, Kim J, Han NA, Nickie A, Park S, Wang K, Yan P, Divaker S, Tabita-Martinez J, Giles L, Carberry M, Beltra JC, Painter MM, Alanio C, Amaravadi RK, Schuchter LM, Carreno BM, Linette GP, Elder DE, Brody RM, Gimotty P, Miura JT, Karakousis GC, Xu X, Mitchell TC, Huang AC: Antigen-specific profiling identifies T-bet(+) melanoma-specific CD8(+) T cells associated with response to neoadjuvant PD-1 blockade. Cancer Cell 44(1), January 2026.

Ma KL, Mitchell TC, Dougher M, Sharon CE, Tortorello GN, Elder DE, Morgan EE, Gimotty PA, Huang AC, Amaravadi RK, Schuchter LM, Flowers A, Miura JT, Karakousis GC, Xu X: Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells. Science Advances 11(3), January 2025.

Ma KL, Mitchell TC, Dougher M, Sharon CE Tortorello GN, elder DE, Morgan EE, Gimotty PA, Huang AC, Amaravadi RK, Schuchter LM, Flowers A, Muira JT, Karakousis GC, Xu X.: Tumor-infiltrating lymphocytes in necrotic tumors after melanoma neoadjuvant anti-PD1 therapy correlate with pathologic response and recurrence-free survival. Clin Cancer Res. 30(21), November 2024.

1. Wang K, Coutifaris P, Brocks D, Wang G, Azar T, Solis S, Nandi A, Anderson S, Han N, Manne S, Kiner E, Sachar C, Lucas M, George S, Yan P, Kier M, Laughlin AI, Kothari S, Giles JR. and Mathew D, Ghinnagow R, Alanio C, Flowers A, Xu W, Tenney D, Xu, X, Amaravadi RK, Karakousis GC, Schuchter LM, Buggert M, Oldridge D, Minn A, Blank C, Weber J, Mitchell, TC, Farwell MD, Herati R*, Huang, AC*: Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8 T cells. Cancer Cell 42(9): 1582-1597, September 2024.

Ngiow SF, Manne S, Huang YJ, Azar T, Chen Z, Matthew D, Chen Q, Khan O, Wu JE, ALcade V, Flowers AJ, McClain S, Baxter AE, Kurachi M, Shi J, Huang AC, Giles JR, Sharpe AH, Vignali, DAA, Wherry EJ.: LAB-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK expression and cytotoxicity. Cell 187(16): 4336-4354, August 2024.

Mathew D, Maramareis ME, Foley C, Bauml JM, Ye D, Ghinnagow R, Ngiow SF, Klapholz M, Jun S, Zhang Z, Zorc R, Davis CW, Diehn M, Giles JR, Huang AC, Hwang WT, Zhang NR, Schoenfeld AJ, Carpenter EL, Langer CJ, Wherry EJ, Minn AJ.: Combined JAK Inhibition and PD-1 immunotherapy for non-small cell lung cancer patients. Science 384(6702), June 2024.