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Jeremy Binder Katzen, MD
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Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care)
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Department: Medicine
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Graduate Group Affiliations
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Contact information
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Edward J Stemmler Hall Suite 216
3a 3450 Hamilton Walk
Philadelphia, PA 19104-6118
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3a 3450 Hamilton Walk
Philadelphia, PA 19104-6118
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Email:
jeremy.katzen@uphs.upenn.edu
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jeremy.katzen@uphs.upenn.edu
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Education:
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28 Bowdoin College, 2004.
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51 University of Rochester School of Medicine and Dentistry, 2011.
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Permanent link21 7 BA c
28 Bowdoin College, 2004.
21 7 MD c
51 University of Rochester School of Medicine and Dentistry, 2011.
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1a Pulmonary Fibrosis
28 Genetic Interstitial Lung Disease
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18 Lung Development
1a Surfactant Biology
13 Cell Stress
14 Lung Fibrosis
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Description of Clinical Expertise
2a Interstitial Lung Disease1a Pulmonary Fibrosis
28 Genetic Interstitial Lung Disease
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Description of Research Expertise
28 Lung Epithelial Biology18 Lung Development
1a Surfactant Biology
13 Cell Stress
14 Lung Fibrosis
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146 Murthy A, Rodríguez LR, Roque Barboza W, Tomer Y, Bui S, Carson P, Dimopoulos T, Iyer S, Chavez K, Cooper CH, Katzen JB, Beers MF.: Regulatory T cells protect against aberrant remodeling in a mouse model of pulmonary fibrosis. Mucosal Immunol Dec 2025.
133 Snitow ME, Michki SN, Chaudhry FN, Park Y, Dherwani R, Katzen JB, Frank DB, Zepp JA.: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung. Cell Rep 45: 116750, Dec 2025.
222 Hoffman ET, Shah A, Roque WB, Rodriguez LR, Dherwani R, Dooley PE, Minakin K, Tomer Y, Ayers LJ, Jones D, Murthy M, Bennett A, Lange AN, Babu B, Bawa PS, Wang F, Chavez K, Cooper CH, Nakamoto RS, Basil MC, Brickman MS, Kotton DN, Konstantinos AD, Katzen J: Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling. Nat Commun 16(1), Sep 2025 Notes: doi:10.1038/s41467-025-63735-1 / NCOMMS-24-68971.
271 Omo-Lamai S, Wang Y, Patel MN, Milosavljevic A, Zuschlag D, Poddar S, Wu J, Wang L, Dong F, Espy C, Majumder A, Essien EO, Shen M, Channer B, Papp TE, Tobin M, Maheshwari R, Jeong S, Patel S, Shah A, Murali S, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Discher D, Gaskill PJ, Tsourkas A, Muzykantov VR, Brodsky I, Shin S, Whitehead KA, Parhiz H, Katzen J, Miner JJ, Trauner D, Brenner JS.: Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape. Nat Nanotechnol Aug 2025.
1b5 Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF.: Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. JCI Insight 10: e182578, Jul 2025.
161 Patel MN, Tiwari S, Wang Y, O'Neill S, Wu J, Omo-Lamai S, Espy C, Chase LS, Majumder A, Hoffman E, Shah A, Sárközy A, Katzen J, Pardi N, Brenner JS.: Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids. Nat Biotechnol Feb 2025.
193 Banaschewski BJH, Michki SN, Sitaraman S, Pan R, Wang JY, Stewart D, Goldy MK, Lin SM, Cantu E, Katzen JB, Basil MC, Emtiazjoo AM, Todd JL, Gokey JJ, Kropski JA, Frank DB, Zepp JA, Young LR.: Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis. Commun Biol 8: 284, Feb 2025.
116 Katzen J and Knipe R: Animal and Translational Models for Precision Medicine in ILD. Precision Medicine in Interstitial Lung Disease. Collins BF and Montesi SB (eds.). Springer Nature, Page: 159-175, 2025.
158 Wang JY, Michki SN, Sitaraman S, Banaschewski BJ, Jamal R, Gokey JJ, Lin SM, Katzen JB, Basil MC, Cantu E, Kropski JA, Zepp JA, Frank DB, Young LR.: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight Dec 2024.
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Selected Publications
1e8 Marzolini N, Brysgel TV, Rahman RJ, Essien EO, Nwe SY, Wu J, Majumder A, Patel MN, Tiwari S, Espy CL, Dong F, Santos-De León SA, Shah A, Shuvaev VV, Hood ED, Chase LS, Weissman D, Katzen JB, Frank DB, Bennett ML, Marcos-Contreras OA, Myerson JW, Muzykantov VR, Reyes-Esteves S, Brenner JS.: Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity. Adv Sci (Weinh) Mar 2026.146 Murthy A, Rodríguez LR, Roque Barboza W, Tomer Y, Bui S, Carson P, Dimopoulos T, Iyer S, Chavez K, Cooper CH, Katzen JB, Beers MF.: Regulatory T cells protect against aberrant remodeling in a mouse model of pulmonary fibrosis. Mucosal Immunol Dec 2025.
133 Snitow ME, Michki SN, Chaudhry FN, Park Y, Dherwani R, Katzen JB, Frank DB, Zepp JA.: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through apoptosis in the neonatal lung. Cell Rep 45: 116750, Dec 2025.
222 Hoffman ET, Shah A, Roque WB, Rodriguez LR, Dherwani R, Dooley PE, Minakin K, Tomer Y, Ayers LJ, Jones D, Murthy M, Bennett A, Lange AN, Babu B, Bawa PS, Wang F, Chavez K, Cooper CH, Nakamoto RS, Basil MC, Brickman MS, Kotton DN, Konstantinos AD, Katzen J: Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling. Nat Commun 16(1), Sep 2025 Notes: doi:10.1038/s41467-025-63735-1 / NCOMMS-24-68971.
271 Omo-Lamai S, Wang Y, Patel MN, Milosavljevic A, Zuschlag D, Poddar S, Wu J, Wang L, Dong F, Espy C, Majumder A, Essien EO, Shen M, Channer B, Papp TE, Tobin M, Maheshwari R, Jeong S, Patel S, Shah A, Murali S, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Discher D, Gaskill PJ, Tsourkas A, Muzykantov VR, Brodsky I, Shin S, Whitehead KA, Parhiz H, Katzen J, Miner JJ, Trauner D, Brenner JS.: Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape. Nat Nanotechnol Aug 2025.
1b5 Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF.: Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. JCI Insight 10: e182578, Jul 2025.
161 Patel MN, Tiwari S, Wang Y, O'Neill S, Wu J, Omo-Lamai S, Espy C, Chase LS, Majumder A, Hoffman E, Shah A, Sárközy A, Katzen J, Pardi N, Brenner JS.: Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids. Nat Biotechnol Feb 2025.
193 Banaschewski BJH, Michki SN, Sitaraman S, Pan R, Wang JY, Stewart D, Goldy MK, Lin SM, Cantu E, Katzen JB, Basil MC, Emtiazjoo AM, Todd JL, Gokey JJ, Kropski JA, Frank DB, Zepp JA, Young LR.: Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis. Commun Biol 8: 284, Feb 2025.
116 Katzen J and Knipe R: Animal and Translational Models for Precision Medicine in ILD. Precision Medicine in Interstitial Lung Disease. Collins BF and Montesi SB (eds.). Springer Nature, Page: 159-175, 2025.
158 Wang JY, Michki SN, Sitaraman S, Banaschewski BJ, Jamal R, Gokey JJ, Lin SM, Katzen JB, Basil MC, Cantu E, Kropski JA, Zepp JA, Frank DB, Young LR.: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight Dec 2024.
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