Faculty

Caroline Diorio, MD, MSTR, FRCPC, FAAP

Assistant Professor of Pediatrics (Oncology)

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
Division of Oncology
Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104

Education:
BSc (Biology and Psychology)
Wilfrid Laurier University, 2010.
MD (Medicine)
University of Toronto Faculty of Medicine, 2014.
MTR (Translational Research)
University of Pennsylvania School of Medicine, 2021.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

High risk leukemia, relapsed/refractory T-ALL, HLH, CART

Description of Research Expertise

Serum proteomics, immune dysregulation, T-cell ALL immunotherapy

Selected Publications

Newman H, Hondonga T, Berry A, Elgarten C, Freedman J, Oranges K, McDonough S, Diorio C, Dupuis LL. : Preferences of pediatric patients and their caregivers for chemotherapy-induced nausea and vomiting control endpoints: a mixed methods study. Pediatr Blood Cancer April 2026.

Fensterheim BA, McKeague M, Matthew D, Pattekar A, Nasta S, Kee M, Clendenin C, Martinez Z, Diorio C, Greenplate AR, Lingappan K, Wherry EJ: Perturbation of the Preterm Human Immune System in Early Life. J Clin Investigation March 2026.

Diamond T*, Chapin C*, Diorio C, McCuiag S, Lau M, Chu N, Gibson N, Krieger P, Horslen S, Loomes K, Banc-Husu A, Chu J, Jensen M, Leung D, Narang A, Carter B, Elisofon S, Fischer R, Lobritto S, Leonis M, Peters A, Rodriguez B, Romero R, Rosenthal P, Rdunic D, Squires J, Sundaram S, Tolliver K, Valentino P, Dukalski V, Alonso E, Behrens EM. : A Unique Pediatric Activated T-cell Acute Liver Failure Endotype Characterized by Perforin and Interferon Gamma Expressing Circulating CD8 Tissue Resident Memory T-cells. Hepatol Commun 10(4), March 31 2026.

Diorio C*, Myers RM*, Li Y, Liu H, Belfer S, DiNofia A, Leahy AB, Newman H, Dolan J, Martinez Z, Elhachimi A, Lindell RB, Mullen C, Li A, Kim J, Teachey DT, Maude SL*, Grupp SA*, McGuire JL: Preinfusion Risk Factors for the Development of Severe Neurotoxicity following CART Therapy in Pediatric Patients. HemaSphere February 2026.

Espinoza DA, Zrzavy T, Breville G, Thebault S, Marefi A, Mexhitaj I, Yamashita LD, Kan M, Bacchus M, Legaspi J, Fernandez S, Melamed A, Stubblebine M, Winters A, Virkler A, Helbig I, Kim Y, Martinez Z, Diorio C, Schulte-Mecklenbeck A, Wiendl H, Rezk A, Li R, Narula S, Waldman AT, Hopkins SE, Banwell B, Bar-Or A: Paediatric cerebrospinal fluid immune profiling distinguishes paediatric-onset multiple sclerosis from other paediatric-onset acute neurological disorders. EBioMedicine Page: 123:106088, January 5 2026.

Karki R, Netea MG, Diorio C, Kanneganti TD: Cytokine storm. Nat Rev Dis Primers 12(1): 1, January 15 2026.

Ho M, Paruzzo L, Noll JH, Stella F, Devi P, Ndeupen S, Day YA, Chen GM, Cohen IJ, Ramirez-Fernandez A, Waxman A, Kapur S, Chen F, Xu R, Huff A, Jarocha D, Patel V, Bochi-Layec AC, Ramasubramanian R, Liu S, Bouvier R, de Souza VB, Patel H, Li Z, Carturan A, Michener P, Hopkins CR, Koucky O, Minehart J, Dimitri A, Nabar NR, Hasanali ZS, Ciccarelli BT, Hung P, Williams E, Bartoszek R, Lavorando M, Mohan S, Gonzalez VE, Porazzi P, Bhoj VG, Apostolidis SA, Vogl DT, Porter DL, Scholler J, Diorio C, Roche AM, Everett JK, Bushman FD, Nathanson KL, Stadtmauer EA, Susanibar-Adaniya SP, Garfall AL, Ruella M, Cohen AD, Fraietta JA: CD4+ T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy. Nat Med January 15 2026.

Xu J, McCoy M, Martinez Z, Vincent V, Sussman JH, Wang H, Gao D, Elghawy O, Chen GM, Yang AG, Polonen P, Shraim R, Newman H, Hoffman T, Scoma S, DiNofia A, Hunger SP, Yang JJ, Mullighan CG, Bernt KM, Hexner EO, Grupp SA, Watanabe K, June C, Tan K, Teachey DT, Diorio C. : Anti-CCR4 CAR T cells are efficacious in preclinical models of T-cell acute lymphoblastic leukemia. Blood Adv 2026.

9. Myers RM, Li Y, Liu H, Mumanachit S, Wang L, Leahy AB, Cain LE, DiNofia AM, Diorio C, Freedman JL, Hunger SP, Maude SL, McClory SE, Rheingold SR, Tasian SK, Wray L, Olson TS, Grupp SA, Bunin NJ, Seif AE, Elgarten CW: Hematopoietic cell transplantation after CD19-directed CAR T-cell therapy for remission consolidation or relapse treatment in pediatric acute lymphoblastic leukemia. Haematologica November 27 2025.

McGuire JL, Pinto S, Erdogan EN, Li Y, Bhatia A, Oztek MA, Vossough A, Wright JN, Shah R, Carapia NT, Shams N, Westermann C, Taraseviciute A, Yates B, Naik S, Gardner R, Annesley C, Hsieh E, Diorio C, Myers R, Epperly R, Talleur A, Shalabi H, Shah N, Gust J.: Neuroimaging Findings in Children and Young Adults With Neurotoxicity After CAR T-Cell Therapy for B-Cell Malignancies. Neurology 105(7), Oct 2025.