Faculty
Krithika Lingappan, MBBS, PhD, MS
Associate Professor of Pediatrics (Neonatology & Newborn Services)
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Division of Neonatology
3401 Civic Center Boulevard
Philadelphia, PA 19014
Division of Neonatology
3401 Civic Center Boulevard
Philadelphia, PA 19014
Education:
MBBS (Medicine)
Kilpauk Medical College, MGR Medical University, India, 2002.
MS (Clinical Scientist Training Program)
Baylor College of Medicine, 2012.
PhD (Clinical Scientist Training Program)
Baylor College of Medicine Graduate School of Biomedical Sciences, 2018.
Permanent linkMBBS (Medicine)
Kilpauk Medical College, MGR Medical University, India, 2002.
MS (Clinical Scientist Training Program)
Baylor College of Medicine, 2012.
PhD (Clinical Scientist Training Program)
Baylor College of Medicine Graduate School of Biomedical Sciences, 2018.
Description of Clinical Expertise
I take particular interest in evidence-based medicine (EBM) and have led several EBM initiatives. We are also interested in translational research projects related to long-term outcomes (pulmonary and cardiovascular) after preterm birth. I have leadership experience at national and regional organizations. As the leader of several national-level groups, I have created a unique niche for herself as a leader in the neonatology subspecialty with my involvement in the American Academy of Pediatrics (AAP), Section of neonatal-perinatal medicine (SONPM), NIH-funded lung basic-science research, evidence-based clinical neonatology practice, and trainee engagement and education.Description of Research Expertise
My research focuses on reducing long-term morbidities such as chronic lung disease (bronchopulmonary dysplasia) in premature babies. Specifically, our research focuses on elucidating the mechanisms behind sex-specific differences in the incidence of BPD. In the future, this research should lead to therapeutic lung-protective strategies. There is a great need for such therapeutic strategies to improve outcomes in premature babies, given that the incidence of BPD in premature neonates has been reported to be as high as 50%. The long-term goal of this research is to develop new translational strategies, both therapeutic and diagnostic in the field of neonatal lung injury.Selected Publications
Mueller MC, Gu S, Lingappan K, Dodson RB, Magin CM.: The importance of sex as a biological variable in pulmonary vascular research. Am J Physiol Lung Cell Mol Physiol 330: L708-L712, Jun 2026.Sonti S, Leek C, Lingappan K.: Modulation of alveolar macrophages by sex as a biological variable. Am J Physiol Lung Cell Mol Physiol 330: L530-L538, May 2026.
Fensterheim BA, McKeague ML, Mathew D, Shwetank, Pattekar A, Lee M, Rangwala Z, Nasta S, Kee MC, Clendenin C, Martinez Z, Diorio C, Greenplate AR, Lingappan K, Wherry EJ.: Perturbation of the preterm human immune system in early life. JCI Insight Apr 2026.
Starr MC, Griffin R, Steflik HJ, Lingappan K, Gillen M, Selewski DT, Askenazi DJ, Menon S, Slagle CL, Soranno DE.: Examining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study. Pediatr Nephrol Mar 2026.
Liao J, Longoria C, Lal CV, Cheong N, McCurnin DC, Blanco C, Cantu A, Lingappan K, Jehrio MG, Misra RS, Pryhuber GS, Petovari G, Reszegi A, Savani RC.: CD44 is critical for TLR4-mediated NLRP3 inflammasome activation and the development of BPD. Am J Respir Cell Mol Biol Feb 2026.
Manuel Cantu Gutierrez, Abiud Cantu, Krithika Lingappan: "Impact of Antenatal Corticosteroids on the Developing Lung at Single-Cell Resolution" Poster Presentation # 915 ATS 2026 Meeting, Orlando, FL 2026.
Han Pi Chang, Manuel Cantu Gutierrez, Aboud Cantu, Krithika Lingappan: "Endothelial HIF-1α Is Essential for Vascular and Alveolar Development in a Neonatal Murine Model of Bronchopulmonary Dysplasia" Poster Presentation #1018 American Thoracic Society 2026, Orlando, FL 2026.
Sonti S, Cantu A, Cantu Guttierez M, Leek C, Pelton P, Jensen EA, Lingappan K.: Patient-derived lung organoids from bronchoalveolar lavage capture epithelial heterogeneity and disease biology in bronchopulmonary dysplasia. Redox Biol 2026.
Rojas-Quintero J, Faner R, Chiu CY, Kue JT, Zhang Y, Sanz Rubio D, Colborg AS, Jakwerth CA, Schmidt-Weber CB, Maitland-van der Zee AH, Abdel-Aziz MI, Pilon AL, Owen CA, Plosa EJ, Kinney GL, Mc-Grath Morrow S, Gazzaneo MG, Cortes Santiago N, Lingappan K, Ledford J, Spence J, Sucre JM, Sauler M, Wu TD, Agusti A, Wheelock A, Illi S, von Mutius E, Bowler RP, Celli B, Abman SH, Wells JM, Polverino F; ALLIANCE study group, ECLIPSE and COPDGene investigators.: Maternal Smoking and CC-16: Implications for Lung Development and COPD Across the Lifespan. Am J Respir Crit Care Med Page: doi: 10.1164, Oct 2025 Notes: epub ahead of print.
Fensterheim BA, McKeague M, Mathew D, Shwetank, Pattekar A, Nasta S, Kee M, Clendenin C, Martinez Z, Diorio C, Greenplate AR, Lingappan K, Wherry EJ.: Perturbation of the Preterm Human Immune System in Early Life. medRxiv Page: doi: 10.1101/2025.09.03.25334934, Sep 2025 Notes: epub.
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