Faculty

Kaoru Takasaki, MD

Assistant Professor of Pediatrics (Hematology) at the Children's Hospital of Philadelphia

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
3615 Civic Center Boulevard
Abramson Research Center, Room 316I
Philadelphia, PA 19104

Education:
AB (Chemistry)
Harvard University, 2010.
MD
Yale University School of Medicine, 2016.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Takasaki K, Shalaby C, Wafula EK, Chou ST, Thom CS: Single-cell atlas identifies transcriptional aberrances during Trisomy 21-related blood cell maturation. Trisomy 21 Research Society 6th International Conference, Denver, CO. Jun 2026.

Herrera K, Takasaki K, Murayama T: Targeting R-loops: diverse RNA helicases in R-loop resolution and their potential as targets for cancer therapy. Front Cell Dev Biol 14: 1822277, Apr 2026.

Gunawardena N, An HH, Veliquette RW, Carvalho E, Dalui S, Takasaki K, Wafula E, French DL, Pavani G, Chou ST: Rare antigen negative red blood cells from pluripotent stem cells for precision transfusion medicine. Transfusion Apr 2026.

Pavani G, Willett CJ, Takasaki K, Dalui S, Keough M, Gadue P, French DL, Chou ST.: Using iPSC-derived hematopoietic stem cells with long-term engraftment capability to model fetal blood disorders. Blood 146: 2156, Nov 2025.

Takasaki K, Murphy K, Wafula EK, Soni L, Sit YT, Gagne A, Thom CS, French DL, Steiner LA, Chou ST: Dysregulated GATA1s chromatin occupancy in hematopoietic progenitors with trisomy 21 leads to immature, cytokine-independent megakaryopoiesis. NHLBI Regenerative Medicine Summit, Bethesda, MD. Sep 2025. Notes: Poster.

Charles S, Gileta A, Mewha J, Luke T, Squicciarini JT, Denenberg EH, Fanning EA, Chen J, Moseley A, Wu J, Schubert J, Surrey LF, Zhong Y, Gunawardena N, Takasaki K, Li MM, Chou ST, Luo M: Genetic testing for inherited red blood cell disorders: diagnostic yield and clinical utility. American College of Medical Genetics and Genomics Annual Clinical Genetics Meeting, Los Angeles, CA. Mar 2025. Notes: Poster.

Takasaki K, Wafula EK, Fan JM, Sit YT, Kumar SS, Smith D, Gagne A, Gearhart PA, French DL, Thom CS, Chou ST: Single-cell transcriptomics reveal individual and cooperative effects of Trisomy 21 and GATA1s on hematopoiesis. Stem Cell Rep 20(8): 102577, Aug 2025.

Takasaki K, Murphy K, Wafula EK, Thom CS, Sit YT, Gagne AL, French DL, Steiner LA, Chou ST: Alterations in GATA1s chromatin occupancy in hematopoietic progenitors with trisomy 21 lead to hyperproliferative, cytokine-independent megakaryopoiesis. American Society of Hematology 66th Annual Meeting and Exposition, San Diego, CA. Dec 2024. Notes: Poster.

Takasaki K, Wafula EK, Smith D, Kumar SS, Gagne A, French DL, Thom CS, Chou ST: Single-cell transcriptomics reveal perturbations in hematopoietic lineage maturation driven by Trisomy 21 and GATA1s. International Society for Experimental Hematology 53rd Annual Scientific Meeting, Chicago, IL. Aug 2024. Notes: Poster.

Takasaki K, Wafula EK, Sit YT, Smith D, Kumar SS, Gagne A, French DL, Thom CS, Chou ST: Single-cell transcriptomics reveal altered hematopoietic mechanisms driven by T21 and GATA1s. NIH INCLUDE Investigators Meeting, Bethesda, MD. Apr 2024. Notes: Poster.