Faculty

Scott Michael Gordon, MD, PhD

Assistant Professor of Pediatrics (Neonatology & Newborn Services)

Department: Pediatrics

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Abramson Pediatric Research Center
3615 Civic Center Blvd
11th Floor, Office 1107C
Philadelphia, PA 19104

Office: 503-807-7980

Publications

Search PubMed for articles

Education:
BS (Biology)
Haverford College, 2006.
Ph.D. (Immunology)
University of Pennsylvania School of Medicine, 2011.
M.D.
University of Pennsylvania School of Medicine, 2013.

Links
Search PubMed for articles
Laboratory website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

I am an attending physician in the Neonatal Intensive Care Unit of Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania.

Description of Research Expertise

The Gordon Lab wants to know how the maternal immune system and the developing placenta communicate with each other. Historically, the maternal-fetal interface has been viewed in the same light as other immune-privileged sites in the body, to explain why a mother’s immune system doesn’t view the fetus as a partially foreign organ and reject it. In truth, the maternal-fetal interface is loaded with immune cells that directly interact with fetal cells throughout pregnancy. Likewise, a growing list of inflammatory molecules released by immune cells play key roles to support a healthy pregnancy. If we can understand how these molecules send signals back and forth between mom and fetus, we may be able to change the course of such life-threatening conditions as preeclampsia, intrauterine growth restriction, congenital infections, and premature birth.

Selected Publications

Flannery DD, Cossaboom CM, Flietstra TD, Barboza AZ, Burris HH, Puopolo KM, Gibbons A, Cannon DL, Krapiunaya I, Sayyad L, Sadigh KS, Smith K, Montgomery JM, Shoemaker T, Klena JD, Gordon SM. : Lymphocytic Choriomeningitis Virus Seroprevalence among Urban Pregnant Women and Newborns, Philadelphia, Pennsylvania, USA, 2021. Emerg Infect Dis. 32(3): 324-331, Mar 2026 Notes: doi: 10.3201/eid3203.250910.

Molina-Vidales SR, Poulson MM, Gordon SM: Tac-kling tissue-resident uterine NK cells. Sci Transl Med. 18(840), Mar 2026 Notes: doi: 10.1126/scitranslmed.aec4494.

Abin Abraham, Rebecca L. Linn, Dustin D. Flannery, and Scott M. Gordon: Congenital LCMV infection causes inflammation at the maternal-fetal interface and disrupts placental vasculature. Emerging Infectious Diseases Mar 2026 Notes: Provisionally accepted.

Mingce Zhang, Remy R Cron, Niansheng Chu, Junior Nguyen, Scott M Gordon, Esraa M Eloseily, T Prescott Atkinson, Peter Weiser, Mark R Walter, Portia A Kreiger, Scott W Canna, Edward M Behrens, Randy Q Cron: Role of DOCK8 in cytokine storm syndromes. The Journal of Allergy and Clinical Immunology Oct 2024 Notes: DOI: 10.1016/j.jaci.2024.10.004.

Shelley M. Lawrence, James L. Wynn, and Scott M. Gordon: Bacterial Sepsis. Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 9th Edition. Yvonne Maldonado, Victor Nizet, Elizabeth D. Barnett, Kathryn M. Edwards, Richard Malley (eds.). Elsevier, April 2024 Notes: Chapter.

Scott M. Gordon, Shelley M. Lawrence, and James L. Wynn: Bacterial Meningitis. Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 9th Edition. Yvonne Maldonado, Victor Nizet, Elizabeth D. Barnett, Kathryn M. Edwards, Richard Malley (eds.). Elsevier, April 2024 Notes: Chapter.

Mani S, Garifallou J, Kim SJ, Simoni MK, Huh DD, Gordon SM*, Mainigi M*.: Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties. Front Immunol 15(1): 1364036, Mar 2024 Notes: Co-senior author.

Olivieri NR, Othman L, Flannery DD, Gordon SM.: Transmission, seroprevalence, and maternal-fetal impact of lymphocytic choriomeningitis virus. Pediatr Res 95(2): 456-463, Jan 2024.

Olivieri NR, Othman L, Gordon SM.: Health disparities revealed in a case of congenital LCMV. Pediatr Res 95(2): 579-580, Jan 2024.

Dar AA, Kim DD, Gordon SM, Klinzing K, Rosen S, Guha I, Porter N, Ortega Y, Forsyth KS, Roof J, Fazelinia H, Spruce LA, Eisenlohr LC, Behrens EM, Oliver PM.: c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8(+) T cell immunity. Nat Commun 14(1): 7098, Nov 2023.