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Brian D. Keith
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Adjunct Professor of Cancer Biology
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Department: Cancer Biology
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Graduate Group Affiliations
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Contact information
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Abramson Family Cancer Research Institute
22 University of Pennsylvania
16 453 BRB II/III
32 421 Curie Blvd.
Philadelphia, PA 19104
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22 University of Pennsylvania
16 453 BRB II/III
32 421 Curie Blvd.
Philadelphia, PA 19104
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Office: 215 746-5533
32 Fax: 215 746-5511
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32 Fax: 215 746-5511
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Email:
bkeith@mail.med.upenn.edu
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bkeith@mail.med.upenn.edu
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Publications
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Education:
21 9 Sc B 14 (Biology) c
29 Brown University, 1980.
21 a Ph.D. 24 (Plant Molecular Biology) c
33 The Rockefeller University, 1987.
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21 9 Sc B 14 (Biology) c
29 Brown University, 1980.
21 a Ph.D. 24 (Plant Molecular Biology) c
33 The Rockefeller University, 1987.
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Links
ea Search PubMed for articles
45 Cell and Molecular Biology graduate group faculty webpage.
7b Abramson Family Cancer Research Institute
78 Department of Cancer Biology faculty
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Permanent linkea Search PubMed for articles
45 Cell and Molecular Biology graduate group faculty webpage.
7b Abramson Family Cancer Research Institute
78 Department of Cancer Biology faculty
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61 How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
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4d Key words: mouse, development, transcription, hypoxia, cancer.
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26 Description of Research
221 As part of a long-standing collaboration with Dr. Celeste Simon, I generate mouse models in which genes encoding critical components of the hypoxic response pathway are mutated. These and related genetic and cell biological tools offer insights into physiological and metabolic responses to hypoxia and other tumor microenvironmental stresses. Previously, I also collaborated with Dr. Carl June on adapting CAR-T cell therapy to solid tumors, focusing on the effects of the tumor microenvironment on CAR-T cell metabolism and function.
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20 Rotation Projects
a1 Students interested in rotation projects should refer to Dr. Celeste Simon's lab page.
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1e Lab personnel:
2e Please refer to Dr. Celeste Simon's lab
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Description of Research Expertise
2a Research Interests61 How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
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4d Key words: mouse, development, transcription, hypoxia, cancer.
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26 Description of Research
221 As part of a long-standing collaboration with Dr. Celeste Simon, I generate mouse models in which genes encoding critical components of the hypoxic response pathway are mutated. These and related genetic and cell biological tools offer insights into physiological and metabolic responses to hypoxia and other tumor microenvironmental stresses. Previously, I also collaborated with Dr. Carl June on adapting CAR-T cell therapy to solid tumors, focusing on the effects of the tumor microenvironment on CAR-T cell metabolism and function.
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20 Rotation Projects
a1 Students interested in rotation projects should refer to Dr. Celeste Simon's lab page.
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1e Lab personnel:
2e Please refer to Dr. Celeste Simon's lab
26 29
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195 Mathew, L.K., Skuli, N., Mucaj, V., Lee, S.S., Zinn, P.O., Sathyan, P., Imtiyaz, H.Z., Zhang, Z., Davuluri, R.V., Rao, S., Venneti, S., Lal, P., Lathia, J.D., Rich, J.N., Keith, B., Minn, A.J., Simon, M.C. : miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proc. Nat. Acad. Sci. USA 111: 291-296., Jan 2014.
143 Mathew L.K., Lee, S.S., Skuli, N., Rao, S., Keith, B., Nathanson, K.L., Lal, P., Simon, M.C. : Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinoma enhances HIF-2 activity. Cancer Discovery 4: 53-60, Jan 2014.
17d Arsenault Patrick R, Pei Fei, Lee Rebecca, Kerestes Heddy, Percy Melanie J, Keith Brian, Simon M Celeste, Lappin Terence R J, Khurana Tejvir S, Lee Frank S: A Knockin Mouse Model of Human PHD2-Associated Erythrocytosis Establishes a Haploinsufficiency Mechanism. The Journal of biological chemistry Oct 2013.
1ad Young Regina M, Ackerman Daniel, Quinn Zachary L, Mancuso Anthony, Gruber Michaela, Liu Liping, Giannoukos Dionysios N, Bobrovnikova-Marjon Ekaterina, Diehl J Alan, Keith Brian, Simon M Celeste: Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes & development 27(10): 1115-31, May 2013.
160 Skuli N, Majmundar AJ, Krock BL, Mesquita RC, Mathew LK, Quinn ZL, Runge A, Liu L, Kim MN, Liang J, Schenkel S, Yodh AG, Keith B, Simon MC: Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J. Clin. Invest. 122(4): 1427-43, Apr 2012.
e1 Keith B, Johnson RS, Simon MC: HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nature Reviews Cancer 12(1): 9-22, Jan 2012.
181 Skuli, N., Majmundar, A., Mesquita, R., Quinn, Z., Runge, A., Liu, L., Gruber, M., Kim, M., Liang, J., Schenkel, S., Yodh, A., Keith, B., and Simon, M.C: Endothelial hypoxia inducible factor-2 (HIF-2) regulates murine pathological angiogenesis and revascularizaiton. J. Clin. Invest. 122 : 1427-1443, 2012.
14e Imtiyaz HZ, Williams EP, Hickey MM, Patel SA, Durham AC, Yuan L-J, Hammond R, Gimotty PA, Keith B, and Simon MC.: Hypoxia factor 2-alpha regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Invest. 120(8): 2699-714, July 2010.
11d Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, and Haase VH: Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood July 2010.
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Selected Publications
134 Li, B., Qiu, B., Lee, D.S.M., Walton, Z., Ochocki, J., Mathew, L.K., Mancuso, A., Gade, T.P.F., Keith, B., Nissim, I., and Simon, M.C.: Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513: 251-255, Sept 2014.195 Mathew, L.K., Skuli, N., Mucaj, V., Lee, S.S., Zinn, P.O., Sathyan, P., Imtiyaz, H.Z., Zhang, Z., Davuluri, R.V., Rao, S., Venneti, S., Lal, P., Lathia, J.D., Rich, J.N., Keith, B., Minn, A.J., Simon, M.C. : miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proc. Nat. Acad. Sci. USA 111: 291-296., Jan 2014.
143 Mathew L.K., Lee, S.S., Skuli, N., Rao, S., Keith, B., Nathanson, K.L., Lal, P., Simon, M.C. : Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinoma enhances HIF-2 activity. Cancer Discovery 4: 53-60, Jan 2014.
17d Arsenault Patrick R, Pei Fei, Lee Rebecca, Kerestes Heddy, Percy Melanie J, Keith Brian, Simon M Celeste, Lappin Terence R J, Khurana Tejvir S, Lee Frank S: A Knockin Mouse Model of Human PHD2-Associated Erythrocytosis Establishes a Haploinsufficiency Mechanism. The Journal of biological chemistry Oct 2013.
1ad Young Regina M, Ackerman Daniel, Quinn Zachary L, Mancuso Anthony, Gruber Michaela, Liu Liping, Giannoukos Dionysios N, Bobrovnikova-Marjon Ekaterina, Diehl J Alan, Keith Brian, Simon M Celeste: Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes & development 27(10): 1115-31, May 2013.
160 Skuli N, Majmundar AJ, Krock BL, Mesquita RC, Mathew LK, Quinn ZL, Runge A, Liu L, Kim MN, Liang J, Schenkel S, Yodh AG, Keith B, Simon MC: Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J. Clin. Invest. 122(4): 1427-43, Apr 2012.
e1 Keith B, Johnson RS, Simon MC: HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nature Reviews Cancer 12(1): 9-22, Jan 2012.
181 Skuli, N., Majmundar, A., Mesquita, R., Quinn, Z., Runge, A., Liu, L., Gruber, M., Kim, M., Liang, J., Schenkel, S., Yodh, A., Keith, B., and Simon, M.C: Endothelial hypoxia inducible factor-2 (HIF-2) regulates murine pathological angiogenesis and revascularizaiton. J. Clin. Invest. 122 : 1427-1443, 2012.
14e Imtiyaz HZ, Williams EP, Hickey MM, Patel SA, Durham AC, Yuan L-J, Hammond R, Gimotty PA, Keith B, and Simon MC.: Hypoxia factor 2-alpha regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Invest. 120(8): 2699-714, July 2010.
11d Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, and Haase VH: Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood July 2010.
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