Faculty

Charles E. Leonard, PharmD, MSCE, MPH, FISPE

Associate Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania

Department: Biostatistics and Epidemiology

Graduate Group Affiliations

Graduate Group in Epidemiology and Biostatistics

Contact information

Perelman School of Medicine at the University of Pennsylvania
Floor 4W, 105D
3600 Civic Center Blvd.
Philadelphia, PA 19104

Office: 215-573-2663
Lab: 215-573-2663

Email:
celeonar@pennmedicine.upenn.edu

Education:
PharmD (Clinical Pharmacy)
Duquesne University, 2001.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2011.
MPH (Public Health)
Yale University, 2025.

Links
ResearchGate Profile
UPenn DBEI Faculty Page
Wikidata
Google Scholar Profile
LinkedIn Profile
UPenn CCEB Senior Scholar Page
UPenn LDI Faculty Page
UPenn PSOM Faculty Page

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

pharmacy

Description of Research Expertise

epidemiology, pharmacoepidemiology, real-world evidence, comparative effectiveness, comparative safety, observational studies, cohort, case-control, self-controlled case series, case-crossover, pharmacovigilance, Medicaid, Medicare, drug interactions, sudden cardiac arrest, ventricular arrhythmia, diabetes, hypoglycemia, diabetic ketoacidosis, ischemic stroke, propensity scores, high-dimensional propensity scores, causal inference

Selected Publications

Pham Nguyen TP, Hennessy S, Brensinger CM, Bilker WB, Dember LM, Miano TA, Vo T, Willis AW, Leonard CE: Impact of empiric potassium supplementation on mortality, sudden cardiac arrest, and stroke in furosemide initiators. Br J Clin Pharmacol [in press] 2026.

Nock MR, Ahn S, Leonard CE, Ogdie A, Cohen JM: Ambient temperature and psoriatic arthritis odds among patients with psoriasis: A cross-sectional analysis. J Psoriasis Psoriatic Arthritis [in press] 2026.

Harris DA, D'Amico A, Mehta HB, Daiello LA, Berry SD, Leonard CE, Hsu YC, Kiel D, Hayes KN, Riester M, Roberts JE, Reich L, Free P, Zullo AR: Identifying observable medication use time in administrative databases: A tutorial using nursing home residents. Am J Epidemiol [in press] 2025.

Pham Nguyen TP, Leonard CE, Brensinger CM, Bilker WB, Chung SP, Horn JR, Bogar K, Miano TA, Hennessy S: Effect of concomitant use of oral anticoagulants and oral dipeptidyl peptidase-4 inhibitors on serious bleeding events. Clin Pharmacol Ther 117(4): 1012-1016, Apr 2025.

Leonard CE, Bogar K, Brensinger CM, Bilker WB, Bell ML, Flory JH, Shi C, Chen C, Hennessy S.: Do relationships between ambient temperature and serious adverse health outcomes vary among users of different antidiabetes drugs? A retrospective cohort study of United States Medicaid beneficiaries with type 2 diabetes. BMJ Open 14: e085139, Oct 2024 Notes: doi:10.1136/ bmjopen-2024-085139.

Dhopeshwarkar N, Yang W, Hennessy S, Rhodes JM, Cuker A, Leonard CE: SuperLearner with high-dimensional propensity score to improve confounding adjustment: A real-world application in chronic lymphocytic leukemia. Pharmacoepidemiol Drug Saf 33(1): e5678, Jan 2024.

Dhopeshwarkar N, Yang W, Hennessy S, Rhodes JM, Cuker A, Leonard CE.: Bleeding with concomitant ibrutinib and oral anticoagulant therapy: A population-based cohort study. Am J Hematol 98(3): E49-E52, Mar 2023.

Dawwas GK, Leonard CE, Lewis JD, Cuker A.: Risk for Recurrent Venous Thromboembolism and Bleeding With Apixaban Compared With Rivaroxaban: An Analysis of Real-World Data. Ann Intern Med 175(1): 20-28, Jan 2022.

Medaglio D, Stephens-Shields AJ, Leonard CE.: Research and scholarly methods: Propensity scores. J Am Coll Clin Pharm 5(4): 467-475, Apr 2022.

Bogar K, Brensinger CM, Hennessy S, Flory JH, Bell ML, Shi C, Bilker WB, Leonard CE.: Climate change and ambient temperature extremes: Association with serious hypoglycemia, diabetic ketoacidosis, and sudden cardiac arrest/ventricular arrhythmia in persons with type 2 diabetes. Diabetes Care 45(11): e171-e173, Nov 2022.