Faculty

Richard Aplenc, MD, PhD, MSCE

Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia

Department: Pediatrics

Contact information

Colket Translational Research Building
Office 4060
3501 Civic Center Blvd
Philadelphia, PA 19104

Office: 267-426-7252

Email:
aplenc@chop.edu

Education:
A.B. (Classics)
Princeton University, 1988.

University of Pennsylvania, Post-Baccalaureate Pre-Health Program, 1989.
MD
University of Virginia, 1994.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2002.
PhD (Epidemiology)
University of Pennsylvania, 2011.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Zwaan CM, Tasian SK, Aplenc R, Brodersen LE, Buldini B, Moreloose BD, Dworzak MN, Fogelstrand L, Gibson BE, Goemans BF, Hasle H, Hirsch BA, Kaspers GJ, Klusmann J, Kutny MA, Lehrnbecher T, Locatelli F, Meshinchi S, Petit A, Pigazzi M, Tierens A, Kolb EA, Reinhardt D, Tomizawa D, Cooper TM: Diagnosis and Management of AML in Pediatric Patients: Consensus Recommendations from an International Expert Panel. Blood 147(14): 1532-1561, Apr 2026 Notes: doi: 10.1182/blood.2024027904.

Miller TP, Aplenc R, Minard C, Lensing S, Wang Y, Velamuru P, Foster JH, Silverman M, Sung C, Wong K, Beeles T, Fangusaro J, Weigel BJ, Onar-Thomas A, Fox E: Feasibility of Automated Laboratory Data Ascertainment and Transfer From Hospitals Into Medidata Rave Across Pediatric National Cancer Institute-Supported Cooperative Groups. JCO Clin Cancer Inform 10(2): e2500359, Apr 2026 Notes: doi: 10.1200/CCI-25-00359.

Zheng DJ, Hettinger G, Aftandilian C, Bona K, Caywood EH, Collier AB, Elgarten CW, Gathers C, Ghosh T, Gramatges MM, Henry M, Huang YV, Li Y, Lotterman C, Maloney K, Mian A, Miller TP, Modi A, Mody R, Morgan E, Myers R, Newman H, Ortiz J, Seif AE, Smith C, Stokke J, Wang X, Winick N, Wilkes JJ, Wong V, Aplenc R, Getz KD: Real-world generalizability of clinical trial cytomolecular risk in pediatric acute myeloid leukemia: a report from the REAL-AML cohort. J Natl Cancer Inst 118(4): 746-750, Apr 2026 Notes: doi: 10.1093/jnci/djaf234.

Chinnabhandar V, Verneris MR, Schultz KR, Gamis AS, Aplenc R, Hudson CA, Alonzo TA, Gerbing RB, Horan JT, Chewning JH: HLA-DR expression at diagnosis is not predictive of relapse risk post allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Haematologica Mar 2026 Notes: doi: 10.3324/haematol.2025.288751.

Newman H, Lee SHR, Pölönen P, Shraim R, Li Y, Liu H, Aplenc R, Bandyopadhyay S, Chen C, Devidas M, Diorio C, Dunsmore K, Elghawy O, Elhachimi A, Fuller T, Gupta S, Hall J, Hughes AD, Hunger SP, Loh ML, Martinez Z, McCoy MF, Mullen CG, Pounds SB, Raetz E, Seffernick AE, Shi G, Sussman J, Tan K, Uppuluri L, Vincent TL, Wang'ondu R, Winestone LE, Winter SS, Wood BL, Wu G, Xu J, Yang W, Mullighan CG, Yang JJ, Bona K, Teachey DT: Correction: Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia. Blood Cancer Discov 7(2): 331, Mar 2026 Notes: doi: 10.1158/2643-3230.BCD-25-0464.

Zheng DJ, Bhatia S, Mirzaei S, Aplenc R, Armstrong GT, Bona K, Brinkman TM, Brouwers P, Edelstein K, Getz K, Huang I, Kirchhoff AC, Mostoufi-Moab S, Park ER, Snyder C, Yabroff KR, Yasui Y, Krull K, Nathan PC: Neurocognitive impairment and financial hardship in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst Jan 2026 Notes: doi: 10.1093/jnci/djaf383.

Naik S, Aplenc R, Baumeister SH, Becilli M, Bhagwat AS, Bonifant CL, Budde LE, Chien CD, Curran KJ, Daniyan AF, Dreyzin A, Gardner RA, Ghorashian S, Gottschalk S, Hill LC, Kohler ME, Lamble A, Locatelli F, Mamonkin M, Omer B, Park JH, Quintarelli C, Rambaldi B, Richards RM, Sallman DA, Sauer T, Shah NN, Subklewe M, Summers C, Tasian SK, Taylor N, Tettamanti S, Verneris MR, Velaquez Gill SI: International consensus guidelines for the conduct and reporting of CAR T-cell clinical trials in AML. Blood Adv 9(23): 6047-6058, Dec 2025 Notes: doi: 10.1182/bloodadvances.2025017011.

Zheng DJ, Hettinger G, Bender JD, Boulter AC, Cao L, Elgarten CW, Fisher BT, Gathers C, Huang YV, Ko J, Leger KJ, Li Y, Myers R, Narayan HK, Ortiz J, Seif AE, Vasileiadi E, Aplenc R, Getz KD: National Trends in Dexrazoxane and Cardiovascular Health Care Utilization for Children With Acute Myeloid Leukemia. JAMA Oncol 11(12): 1545-1548, Dec 2025 Notes: doi: 10.1001/jamaoncol.2025.4365.

Vasileiadi E, Elgarten CW, Getz KD, Aplenc R, Fisher BT: Fluoroquinolone Susceptibility and Comparative Outcomes of Gram-negative Bloodstream Infection in Pediatric Patients With Hematologic Malignancy. J Pediatric Infect Dis Soc 14(10), Oct 2025 Notes: doi: 10.1093/jpids/piaf091.

Vasileiadi E, Elgarten CW, Getz KD, Aplenc R, Fisher BT: Fluoroquinolone Susceptibility and Comparative Outcomes of Gram-negative Bloodstream Infection in Pediatric Patients with Hematologic Malignancy. J Pediatric Infect Dis Soc. Oct 2025 Notes: doi: 10.1093/jpids/piaf091.