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MacLean Nasrallah, MD PhD
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Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
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Staff pathologist, Hospital of the University of Pennsylvania
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Associate Vice Chair for Research, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
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Department: Pathology and Laboratory Medicine
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Contact information
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Hospital of the University of Pennsylvania
f FO6.089
32 3400 Spruce St.
Philadelphia, PA 19104
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f FO6.089
32 3400 Spruce St.
Philadelphia, PA 19104
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Publications
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Links
b5 Search PubMed for articles
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b5 Search PubMed for articles
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Education:
21 7 AB 18 (Mathematics) c
2b Harvard University, 1997.
21 8 PhD 19 (Neuroscience) c
33 University of Pennsylvania, 2010.
21 7 MD c
33 University of Pennsylvania, 2012.
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Permanent link21 7 AB 18 (Mathematics) c
2b Harvard University, 1997.
21 8 PhD 19 (Neuroscience) c
33 University of Pennsylvania, 2010.
21 7 MD c
33 University of Pennsylvania, 2012.
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2c molecular pathology of neuropathology
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19 brain development
30 in utero electroporation in mouse models
18 molecular biology
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Description of Clinical Expertise
1f neuropathology2c molecular pathology of neuropathology
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Description of Research Expertise
43 artificial intelligence in brain tumor diagnostics19 brain development
30 in utero electroporation in mouse models
18 molecular biology
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157 Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder ZA, Lustig RA, O'Rourke DM, Brem S, Desai AS, Nasrallah MP: Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma. J Neurooncology 141(2): 421-429, Jan 2019.
22e Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM: Epidermal growth factor receptor extracellular domain mutations in glioblastoma present opportunities for clinical imaging and therapeutic development. Cancer Cell 34(1): 163-177, Jul 2018.
164 Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C: In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature. Neuro Oncol 20(8): 1068-1079, Jul 2018.
19a Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C: Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1. Sci Rep 8(1): 5087, Mar 2018.
1fb O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med 9(399): 399, Jul 2017.
193 Zeh R, Sheikh S, Xia L, Pierce J, Newton A, Predina J, Cho S, Nasrallah M, Singhal S, Dorsey J, Lee JYK: The second window ICG technique demonstrates a broad plateau period for near infrared fluorescence tumor contrast in glioblastoma. PLoS One 12(7): e0182034, Jul 2017 Notes: doi: 10.1371/journal.pone.0182034. eCollection 2017.
155 Pierce JT, Cho SS, Nag S, Zeh R, Jeon J, Holt D, Durham A, Nasrallah MP, Singhal S, Lee JYK: Folate receptor overexpression in human and canine meningiomas-immunohistochemistry and case report of intraoperative molecular imaging. Neurosurgery 85(3): 359-368, Sep 2019.
176 Nabavizadeh SA, Pechersky D, Schmitt JE, Nasrallah M, Wolf R, Loevner L, Mamourian AC: Perilesional hyperintensity on T1-weighted images in intra-axial brain masses other than cavernous malformations. J Neuroimaging 5: 531-538, Sep 2017 Notes: First published: 18 January 2017. DOI: 10.1111/jon.12424.
165 Verma G, Mohan S, Nasrallah MP, Brem S, Lee JY, Chawla S, Wang S, Nagarajan R, Thomas MA, Poptani H: Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla. J Transl Med 14(1): 274, Sep 2016.
103 Marsh ED, Nasrallah MP, Walsh C, Murray KA, Nicole Sunnen CN, McCoy A, Golden JA: Developmental interneuron subtype deficits after targeted loss of Arx. BMC Neurosci 17(1): 35, Jun 2016.
167 Piazza MA, Ramayya AG, Geiger GA, Alonso-Basanta M, Nasrallah MP, Welch WC, Ozturk AK: Intramedullary recurrence of a thoracic meningioma-presentation of an unusual case and review of the literature. World Neurosurg 92(no issue): 588.e17-588.e21, Aug 2016 Notes: Case report and review.
fc Cho G, Nasrallah MP, Lim Y, Golden JA: Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations. Neurogenetics 13(1): 23-9, Feb 2012.
118 Nasrallah MP, Cho G, Simonet JC, Putt ME, Kitamura K, Golden JA: Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression. Hum Mol Genet 21(5): 1090-8, Mar 2012.
10d Nasrallah IM, McManus MF, Pancoast MM, Wynshaw-Boris A, Golden JA: Analysis of non-radial interneuron migration dynamics and its disruption in Lis1+/- mice. J Comp Neurol 496(6): 847-58, Jun 2006.
123 Pancoast M, Dobyns W, Golden JA: Interneuron deficits in patients with the Miller-Dieker syndrome. Acta Neuropathol 109(4): 400-4, Apr 2005 Notes: Comparative study; Published under Dr. MacLean Nasrallah's maiden name.
13a McManus MF, Nasrallah IM, Pancoast MM, Wynshaw-Boris A, Golden JA: Lis1 is necessary for normal non-radial migration of inhibitory interneurons. Am J Pathol 165(3): 775-84, Sep 2004 Notes: Published under Dr. MacLean Nasrallah's maiden name.
12e Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M: 19-year-old male with headaches and a possible seizure. Brain Pathol 27(4): 557-558, Jul 2017.
17e Henrickson SE, Walter JE, Quinn C, Kanakry JA, Bardakjian T, Dimitrova D, Ujhazi B, Csomos K, Bosticardo M, Dobbs K, Nasrallah M, Notarangelo LD, Holland SM, Fadugba O: Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency. J Clin Immunol 38(6): 642–645, Aug 2018.
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Selected Publications
f0 Viaene AN, Santi M, Rosenbaum J, Li MM, Surrey LF, Nasrallah MP: SETD2 mutations in primary central nervous system tumors. Acta Neuropathol Commun 6(1): 123, Nov 2018.157 Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder ZA, Lustig RA, O'Rourke DM, Brem S, Desai AS, Nasrallah MP: Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma. J Neurooncology 141(2): 421-429, Jan 2019.
22e Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM: Epidermal growth factor receptor extracellular domain mutations in glioblastoma present opportunities for clinical imaging and therapeutic development. Cancer Cell 34(1): 163-177, Jul 2018.
164 Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C: In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature. Neuro Oncol 20(8): 1068-1079, Jul 2018.
19a Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C: Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1. Sci Rep 8(1): 5087, Mar 2018.
1fb O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med 9(399): 399, Jul 2017.
193 Zeh R, Sheikh S, Xia L, Pierce J, Newton A, Predina J, Cho S, Nasrallah M, Singhal S, Dorsey J, Lee JYK: The second window ICG technique demonstrates a broad plateau period for near infrared fluorescence tumor contrast in glioblastoma. PLoS One 12(7): e0182034, Jul 2017 Notes: doi: 10.1371/journal.pone.0182034. eCollection 2017.
155 Pierce JT, Cho SS, Nag S, Zeh R, Jeon J, Holt D, Durham A, Nasrallah MP, Singhal S, Lee JYK: Folate receptor overexpression in human and canine meningiomas-immunohistochemistry and case report of intraoperative molecular imaging. Neurosurgery 85(3): 359-368, Sep 2019.
176 Nabavizadeh SA, Pechersky D, Schmitt JE, Nasrallah M, Wolf R, Loevner L, Mamourian AC: Perilesional hyperintensity on T1-weighted images in intra-axial brain masses other than cavernous malformations. J Neuroimaging 5: 531-538, Sep 2017 Notes: First published: 18 January 2017. DOI: 10.1111/jon.12424.
165 Verma G, Mohan S, Nasrallah MP, Brem S, Lee JY, Chawla S, Wang S, Nagarajan R, Thomas MA, Poptani H: Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla. J Transl Med 14(1): 274, Sep 2016.
103 Marsh ED, Nasrallah MP, Walsh C, Murray KA, Nicole Sunnen CN, McCoy A, Golden JA: Developmental interneuron subtype deficits after targeted loss of Arx. BMC Neurosci 17(1): 35, Jun 2016.
167 Piazza MA, Ramayya AG, Geiger GA, Alonso-Basanta M, Nasrallah MP, Welch WC, Ozturk AK: Intramedullary recurrence of a thoracic meningioma-presentation of an unusual case and review of the literature. World Neurosurg 92(no issue): 588.e17-588.e21, Aug 2016 Notes: Case report and review.
fc Cho G, Nasrallah MP, Lim Y, Golden JA: Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations. Neurogenetics 13(1): 23-9, Feb 2012.
118 Nasrallah MP, Cho G, Simonet JC, Putt ME, Kitamura K, Golden JA: Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression. Hum Mol Genet 21(5): 1090-8, Mar 2012.
10d Nasrallah IM, McManus MF, Pancoast MM, Wynshaw-Boris A, Golden JA: Analysis of non-radial interneuron migration dynamics and its disruption in Lis1+/- mice. J Comp Neurol 496(6): 847-58, Jun 2006.
123 Pancoast M, Dobyns W, Golden JA: Interneuron deficits in patients with the Miller-Dieker syndrome. Acta Neuropathol 109(4): 400-4, Apr 2005 Notes: Comparative study; Published under Dr. MacLean Nasrallah's maiden name.
13a McManus MF, Nasrallah IM, Pancoast MM, Wynshaw-Boris A, Golden JA: Lis1 is necessary for normal non-radial migration of inhibitory interneurons. Am J Pathol 165(3): 775-84, Sep 2004 Notes: Published under Dr. MacLean Nasrallah's maiden name.
12e Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M: 19-year-old male with headaches and a possible seizure. Brain Pathol 27(4): 557-558, Jul 2017.
17e Henrickson SE, Walter JE, Quinn C, Kanakry JA, Bardakjian T, Dimitrova D, Ujhazi B, Csomos K, Bosticardo M, Dobbs K, Nasrallah M, Notarangelo LD, Holland SM, Fadugba O: Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency. J Clin Immunol 38(6): 642–645, Aug 2018.
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